Top 200 Drugs Podcast – Medications 196-200

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Lansoprazole is a PPI that can be used for GERD, ulcers, and other GI conditions. B12 and magnesium deficiency are possible long-term mineral and vitamin effects.

Augmentin is a combination medication of amoxicillin and clavulanate. It is an antibiotic for infection. Diarrhea is the most common adverse effect.

Lovastatin is a cholesterol-lowering medication. It is often not a preferred statin due to CYP3A4 interaction and it is less potent than other medications.

Valacyclovir is a prodrug that gets converted to acyclovir. It is an antiviral medication and can treat herpes zoster and herpes simplex infections.

Chlorpromazine is a dopamine antagonist that has anticholinergic activity as well. It is a first-generation antipsychotic medication.

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Valacyclovir Pharmacology

Valacyclovir can be used for various viral infections such as herpes virus and varicella.

The primary clinical advantage of valacyclovir compared to acyclovir is that it is dosed less frequently.

Valacyclovir may have some mild CYP1A2 inhibitory effect. I discuss the clinical relevance of this on this episode.

GI upset can occur so I usually recommend to give it with food even though it may be given with or without food.

I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.