Top 200 Drugs Podcast – Drugs 46-50

On this episode, we continue with the Top 200 Drugs podcast. We cover the basics of the following drugs: tizanidine, risperidone, ramipril, pravastatin, and terazosin.

Tizanidine is a skeletal muscle relaxant that has drug interactions via CYP2D6

Risperidone is a 2nd generation antipsychotic. Be on the lookout for EPS, hyperprolactinemia, sedation, and metabolic syndrome.

Ramipril is an antihypertensive agent that is an ACE Inhibitor. Cough and hyperkalemia are two important adverse effects.

Pravastatin is an HMG-CoA reductase inhibitor that lowers LDL levels. It isn’t as potent as other statins and I discuss this on the podcast episode.

Terazosin is a non-selective alpha-blocker that may be used for BPH and hypertension.

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Tizanidine Pharmacology

Tizanidine is primarily broken down by CYP1A2. Ciprofloxacin can inhibit CYP1A2 and cause higher tizanidine concentrations.

Tizanidine has a similar classification as clonidine. Pay attention to adverse effects like hypotension and bradycardia.

When patients taking routine tizanidine stop taking it, there is potential for a discontinuation syndrome that may lead to rebound hypertension.

Dry mouth and CNS depression are common adverse effects of tizanidine.

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Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!