supplements – Real Life Pharmacology

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On this episode, I discuss pyridoxine pharmacology, adverse effects, and important clinical uses.

Pyridoxine is most well known for its potential to reduce the likelihood of isoniazid-induced neuropathy.

Another common indication of pyridoxine is its use for nausea and vomiting associated with pregnancy.

Pyridoxine plays an important role in the production of heme, so deficiency will increase the risk for anemia.

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On this episode of the podcast, I discuss my approach and strategies to handle grapefruit juice interactions.

Grapefruit juice causes drug interactions by inhibiting the CYP enzyme system. More specifically, it inhibits CYP3A4 which is responsible for the breakdown of many medications.

Quantity is always an important consideration when assessing grapefruit juice interactions. The more that is taken, typically, the more drug concentrations will be affected.

It is important to assess the use of grapefruit juice when your patient has a history of cardiovascular disease, cardiac conditions, pain, mental health disease, or gout as some medications used to treat these diseases can interact with grapefruit juice.

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