Tag: rheumatoid arthritis

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Diclofenac Pharmacology Podcast

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On this podcast episode, I discuss diclofenac pharmacology, adverse effects, drug interactions, and much more.

Diclofenac is one of the highest-risk NSAIDs when it comes to cardiovascular risk. You can find more information on this in the Meded101 NSAID comparison table.

Diclofenac carries two boxed warnings. One is for GI bleed risk and the other is for cardiovascular risks.

Anticoagulants, antiplatelets, diuretics, and ACEs/ARBs are all common medication classes that can interact with diclofenac.

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Etanercept Pharmacology Podcast

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On this podcast episode, I cover etanercept pharmacology, adverse effects, drug interactions and much more.

Etanercept is classified as a DMARD but is different from older DMARDs in that it is a biologic agent and needs to be injected.

Vaccination assessment in patients is important prior to initiating etanercept due to the fact that the medication may blunt the effectiveness of the vaccines.

Immunosuppression from etanercept can lead to an increased risk for infection and malignancy.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Support The Podcast and Check Out These Amazing Resources!

NAPLEX Study Materials

BCPS Study Materials

BCACP Study Materials

BCGP Study Materials

BCMTMS Study Materials

Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

Guide to Drug Food Interactions (Amazon Best Seller)

Pharmacy Technician Study Guide by Meded101

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Leflunomide Pharmacology

leflunomide pharmacology

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On this episode, I discuss leflunomide pharmacology. It is classified as a DMARD and is primarily used in rheumatoid arthritis.

Leflunomide carries a boxed warning for hepatoxicity. LFTs must be monitored with its use.

Leflunomide can inhibit CYP2C8 which plays an important role in pioglitazone metabolism. Concentrations of pioglitazone can go up on account of this interaction.

TB screening should be done prior to beginning the immunosuppressant leflunomide.

I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

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Hydroxychloroquine Pharmacology

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Hydroxychloroquine is classified as a DMARD and when used chronically, can be helpful in managing rheumatoid arthritis and Lupus.

There have been reports of QTc prolongation with hydroxychloroquine. While not incredibly common, it is important to remember this consideration in patients at risk for QTc prolongation.

Hydroxychloroquine is associated with causing retinopathy. Routine eye exams for monitoring purposes are critical.

Rarely, hydroxychloroquine can be associated with blood disorders like neutropenia and thrombocytopenia. In addition, alterations in liver function have been reported.

I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!