Tag: osteoporosis

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Top 200 Drugs Podcast – Medications 76-80

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Reglan (metoclopramide) is used for gastroparesis and inhibits gastric smooth muscle by blocking dopamine receptors.

Relafen (nabumetone) is a non-selective inhibition of COX-1/COX-2 which leads to a reduction of inflammation via reduced prostaglandins.

Keflex (cephalexin) is a 1st generation oral cephalosporin that covers common gram positive organisms like Staph and Strep species.

Effexor (Venlafaxine) is an SNRI and inhibits both serotonin and norepinephrine reuptake. Primary uses include anxiety and depression.

Boniva (ibandronate) inhibits osteoclasts which helps treat osteoporosis. Osteoclasts break down bone to help pull calcium into the bloodstream.

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Calcium Carbonate Pharmacology Podcast

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I discuss calcium carbonate pharmacology, adverse effects, drug interactions, and more in this podcast episode.

Calcium tends to have a constipating effect and the higher the dose, the more likely patients are to experience this adverse effect.

Binding interactions are a major problem with oral calcium carbonate. I lay out numerous examples of this on the podcast.

There are a few medications that can increase calcium levels in the blood. Thiazide diuretics are a commonly used antihypertensive that may contribute to hypercalcemia.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

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Pharmacy Technician Study Guide by Meded101

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Denosumab (Prolia) Pharmacology

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On this episode, I discuss denosumab pharmacology, adverse effects, clinical pearls, and drug interactions.

Whenever I see an osteoporosis medication like denosumab used, I review the medications to ensure that we avoid medications that can cause osteoporosis.

Denosumab is often used as a potential alternative in osteoporosis management for those that cannot tolerate bisphosphonates.

We need to monitor calcium levels when using denosumab as levels can be dangerously low, especially when used in combination with other calcium lowering drugs.

Loop diuretics and cinacalcet can have additive hypocalcemia effects when used in combination with denosumab.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Support The Podcast and Check Out These Amazing Resources!

NAPLEX Study Materials

BCPS Study Materials

BCACP Study Materials

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BCMTMS Study Materials

Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

Guide to Drug Food Interactions (Amazon Best Seller)

Pharmacy Technician Study Guide by Meded101

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Calcitonin Pharmacology

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On this episode, I discuss the pharmacology of calcitonin.

Calcitonin has an indication for osteoporosis as well as hypercalcemia.

When considering drug interactions with calcitonin, recall that it can lower calcium levels which could have a cumulative effect when combined with loop diuretics.

Calcitonin nasal spray should be stored upright and primed prior to use.

I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

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Ibandronate Pharmacology

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Ibandronate is a bisphosphonate that can be used in the management of osteoporosis.

Bisphosphonates like ibandronate require a full glass of water for oral administration.

Patients should remain upright for at least 30-60 minutes following taking ibandronate to help reduce the risk of esophagitis.

Osteonecrosis has rarely been associated with bisphosphonates like ibandronate – I’ve discussed a couple of risk factors that may place a patient at higher risk.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

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Alendronate Pharmacology

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Alendronate is a bisphosphonate that is used in the management of osteoporosis.

In this episode, I discuss osteonecrosis risk and what are some of the risk factors that may increase the chances of this very rare adverse effect.

Binding interactions are so critical with alendronate. They can essentially make the drug useless.

Esophageal irritation and ulceration is one of the possible complications with the use of alendronate.

I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!