Tag: neuropathy

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Pregabalin Pharmacology Podcast

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On this podcast episode, I discuss (Lyrica) pregabalin pharmacology, adverse effects, drug interactions, and much more.

I compare pregabalin and gabapentin in this episode and one important difference is the percent absorption of gabapentin compared to pregabalin.

Pregabalin can exacerbate the risk of respiratory depression and overdose in patients who are taking opioids.

Pregabalin is most frequently used in practice for neuropathic pain syndromes.

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Nortriptyline Pharmacology

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Nortriptyline is a TCA that can be used for depression and various pain syndromes. I discuss other less common diagnoses in this podcast episode as well.

There are a lot of drug interactions with nortriptyline. It is metabolized by CYP2D6, can have additive anticholinergic effects and has been associated with QTc prolongation.

Nortriptyline is very anticholinergic and can blunt the effects of dementia medications.

Dry mouth, dry eyes, sedation, urinary retention, and constipation are a few of the more common adverse effects of nortriptyline.

I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!