Tag: naloxone

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Buprenorphine/Naloxone Pharmacology Podcast

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On this episode, I discuss the use of buprenorphine/naloxone in managing opioid use disorder. I cover the kinetics, dosage forms, adverse effect, interactions and much more.

Buprenorphine/naloxone has numerous dosage form and they are not interchangeable. I discuss this further on the podcast.

Liver impairment is a potential reason to avoid the use of buprenorphine. I discuss this on the podcast.

You must keep an eye out for withdrawal symptoms when initiating and adjusting doses of buprenorphine/naloxone. They include sweating, nausea, tachycardia, and mood changes.

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Naloxone Pharmacology

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Naloxone is a life saving drug that can help manage an opioid overdose situation.

Naloxone blocks opioids receptors so opioid agonists cannot bind there.

One of the biggest risks with opioid overdose includes respiratory depression. Naloxone can help reduce the risk of this if administered in a timely manner.

IV naloxone will have the quickest physiological onset of action, but nasal naloxone may be the best opportunity in the community to get this drug on board quickly.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!