Tag: migraine

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Timolol Pharmacology Podcast

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On this episode, I discuss timolol pharmacology, adverse effects, drug interactions, and much more.

Timolol is a non-selective beta-blocker so it blocks both beta-1 and beta-2 receptors.

Since timolol blocks beta-2 receptors, it can blunt the effect of respiratory medications that have beta-agonist action.

Beta-blockers are notorious for causing bradycardia and pulse is an important monitoring parameter for timolol.

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Lasmiditan Pharmacology

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Lasmiditan (Reyvow) is an agent that is utilized for acute migraine treatment. It works slightly differently than triptans which I discuss on this episode.

Lasmiditan is a relatively new agent and cost will often limit its use at this time.

Rosuvastatin and sulfasalazine are two common medications that may have concentrations increase when lasmiditan is used. I discuss this in detail on this episode.

Lasmiditan is an oral tablet that is only recommended to give once per day which differs from commonly used triptans where the dose can be repeated.

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Sumatriptan Pharmacology

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On this episode, I discuss sumatriptan pharmacology, adverse effects, drug interactions and more.

Dosage forms can provide different methods of drug delivery and I talk about many different sumatriptan dosage forms in this episode.

Cardiovascular risks need to be assessed when using a drug like sumatriptan. I discuss this in greater detail in the podcast.

Sumatriptan has serotonergic activity and we need to assess the risk of serotonin syndrome in our patients.

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Topiramate Pharmacology

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On this episode of the Real Life Pharmacology Podcast, I cover topiramate pharmacology.

Topiramate is indicated for migraine prevention, seizures, and weight loss which are the most common uses that I see this medication used for.

Topiramate has carbonic anhydrase activity, so rarely, use of this drug may induce metabolic acidosis.

By far, the most common patient complaint I get with the use of topiramate is that it causes cognitive slowing or impairment.

I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

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