Top 200 Drugs Podcast – Medications 66-70

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Pantoprazole (Protonix) is a PPI that can be used for GERD and peptic ulcer disease. I differentiate why this medication is different from the commonly used omeprazole.

Dicyclomine (Bentyl) is an anticholinergic medication that may be used to help reduce pain and spasms associated with irritable bowel syndrome.

Sumatriptan (Imitrex) is a selective 5HT1 receptor agonist, which potentially helps with vasoconstriction that contributes to migraine symptoms.

Chlorhexidine (Peridex) is an antibiotic oral rinse that can be used for gingivitis.

Metoprolol (Lopressor, Toprol XL) is a beta-blocker that may be used for atrial fibrillation, angina prevention, and hypertension. It is not a first-line medication for hypertension.

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Metoprolol Pharmacology

Metoprolol is a beta-blocker commonly used in the management of hypertension, heart failure, and atrial fibrillation.

There is an extended release dosage form and immediate release dosage form with metoprolol. The advantage of the extended release product is that it doesn’t require as frequent dosing.

Metoprolol is selective for beta-1 receptors. It is less likely to interact with asthma medications.

CYP2D6 plays an important role in breaking down metoprolol. Alterations in this enzyme’s activity can alter concentrations of the drug.

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