Top 200 Drugs Podcast – Drugs 31-35

On this episode of the Real Life Pharmacology podcast, I discuss drugs 31-35 of the top 200 drugs.

Ethinyl estradiol/drospirenone is a combined oral contraceptive used for birth control purposes.

Hydralazine is a direct vasodilatory that can be used for hypertension and heart failure.

Benztropine is an older anticholinergic medication originally indicated for Parkinson’s disease but most commonly used to manage EPS symptoms from dopamine-blocking agents such as antipsychotics.

Tussionex is a combination medication of chlorpheniramine and hydrocodone. It is used to help alleviate cough.

Paroxetine is an SSRI used for the treatment of depression, anxiety, and other psychiatric disorders.

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Top 200 Drugs Podcast – Drugs 21-25

Lamotrigine is an antiseizure medication and also may be used for bipolar disorder. A rash is a major side effect to remember with this medication.

Valganciclovir is an antiviral medication that can be used to prevent cytomegalovirus (CMV) in patients with a suppressed immune system.

Fluconazole is an azole antifungal that can be used to treat candidiasis, blastomycosis, and tinea infections. Drug interactions, QTc prolongation, and hepatotoxicity are potential risks.

Atenolol is a beta-blocker used to treat atrial fibrillation and hypertension. It is relatively selective for beta-1 receptors meaning that it doesn’t affect the lungs as much as non-selective agents.

Montelukast is a medication that blocks the actions of leukotrienes. This can be beneficial for the management of allergies and asthma.

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Timolol Pharmacology Podcast

On this episode, I discuss timolol pharmacology, adverse effects, drug interactions, and much more.

Timolol is a non-selective beta-blocker so it blocks both beta-1 and beta-2 receptors.

Since timolol blocks beta-2 receptors, it can blunt the effect of respiratory medications that have beta-agonist action.

Beta-blockers are notorious for causing bradycardia and pulse is an important monitoring parameter for timolol.

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Antihypertensive Drug Interactions Podcast – Episode 316

On this podcast episode, I discuss some of the most common antihypertensive drug interactions you need to know.

One major interaction I discuss is the trifecta of a diuretic, an ACE or ARB, and an NSAID. This combination significantly increases the risk for acute renal failure.

Nitrates aren’t classically referred to as an antihypertensive but they can definitely cause some problems when combined with PDE5 Inhibitors.

Lithium can interact with 3 blood pressure medication classes. ACEIs, ARBs, and diuretics can all increase the risk for lithium toxicity.

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Captopril Pharmacology Podcast – Episode 314

On this podcast episode, I discuss captopril pharmacology, kinetics, interactions, and much more!

Captopril is an ACE Inhibitor. It can cause hyperkalemia, cough, and renal impairment.

One of the notable issues with captopril is its relatively short half-life which requires it to be dose frequently throughout the day.

Lithium is an important drug interaction and the use of captopril with this medication may increase concentrations and the chance for toxicity.

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Guanfacine Pharmacology Podcast

On this episode of the podcast, I cover guanfacine pharmacology, adverse effects, drug interactions, and much more.

Guanfacine is a central acting alpha-2 agonist that has the brand names of Tenex and Intuniv.

Because of guanfacine’s mechanism of action, it suppresses the sympathetic response leading to a drop in pulse and blood pressure.

It is important to remind patients that the onset of action is slow in the management of ADHD with guanfacine. I discuss this further in this podcast episode.

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Aliskiren Pharmacology Podcast

On this episode, I discuss aliskiren pharmacology, adverse effects, drug interactions, and much more.

Aliskiren should not be used with ACE Inhibitors or ARBs. I discuss why that is in this episode.

Aliskiren has a long enough half-life at approximately 24 hours so it is recommended to only take this once daily.

Hyperkalemia is a major concern with aliskiren. It is important to monitor potassium levels and renal function.

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Spironolactone Pharmacology Podcast

On this episode, I discuss spironolactone pharmacology, adverse effects, drug interactions and much more.

Spironolactone has numerous indications including hypertension, CHF, ascites, and acne. I break them all down in this podcast episode.

Hyperkalemia is a major concern with spironolactone. Patients with baseline levels at 5 or above should generally avoid this medication.

Gynecomastia is one of the most commonly tested adverse effects of spironolactone. Be sure you don’t miss this one on your board and pharmacology exams!

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Enalapril Pharmacology Podcast

On this episode, I discuss enalapril pharmacology, adverse effects, drug interactions, and much more!

Enalapril has a shorter half-life compared to some of the other ACE inhibitors so it may need to be dosed twice daily in patients with adequate renal function.

Hyperkalemia, cough, renal impairment, and angioedema and four adverse effects associated with enalapril that you should monitor for.

NSAIDs and diuretics can increase the risk of acute renal failure when an ACE inhibitor like enalapril is being used.

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Fosinopril (Monopril) Pharmacology Podcast

On this podcast episode, I discuss fosinopril (Monopril) pharmacology, adverse effects, drug interactions and much more.

Fosinopril is an ACE inhibitor so it should absolutely NOT be used in pregnancy as it poses fetus risks.

Like other ACE inhibitors, hyperkalemia, cough, angioedema, and acute renal failure represent possible risks in using fosinopril.

Drugs that can raise potassium when used in combo with fosinopril include spironolactone, trimethoprim, calcineurin inhibitors, and heparin.

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