Tag: estrogen

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Top 200 Drugs – Medications 51-55

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On this episode of the Real Life Pharmacology podcast, I cover medications 51-55. They are eszopiclone, celecoxib, estrogen, moxifloxacin, and donepezil.

Eszopiclone is a “Z” drug used for insomnia. Its adverse effect profile is very similar to benzodiazepines.

Celecoxib is a COX-2 Inhibitor used for pain and inflammation. I discuss how this medication differs from traditional NSAIDs.

Estrogen therapy is used for menopausal symptoms but carries a risk of cancer and blood clots.

Moxifloxacin is a quinolone antibiotic. Binding drug interactions, boxed warnings, and QTc prolongation are potential concerns.

Donepezil is a medication used for dementia. I discuss its mechanism of action and common adverse effects.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

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Conjugated Estrogens Pharmacology

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Conjugated estrogens (Premarin) are most often used in the management of menopausal symptoms.

Estrogen therapy can increase the risk for breast cancer and the risk should be assessed before beginning therapy.

Blood clots are a potential consequence from the use of Premarin. Premarin can oppose the benefit of anticoagulation.

Conjugated estrogens are broken down by CYP3A4. Inhibitors may increase concentrations while inducers may reduce concentrations.

I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!