Tag: drug interactions

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June 15, 2023June 9, 2023

Bexagliflozin Pharmacology Podcast

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On this podcast episode, I discuss bexagliflozin pharmacology, adverse effects, drug interactions, and much more.

I wasn’t wowed by the A1C reduction of this medication. I get into the specifics on bexagliflozin in the podcast episode.

SGLT2 inhibitors like bexagliflozin increase the glucose in the urine which can facilitate the growth of bacteria and fungi in the genitourinary tract.

Limb amputation and euglycemic DKA are two rare, reported adverse effects to be aware of with the use of bexagliflozin.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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June 8, 2023June 5, 2023

Cefuroxime Pharmacology Podcast

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On this episode, I discuss cefuroxime pharmacology, adverse effects, drug interaction, pharmacokinetics, and much more.

Cefuroxime is a 2nd generation cephalosporin that binds Penicillin-binding proteins and prevents bacterial cell wall synthesis.

Medications that create a higher pH in the stomach such as antacids can ultimately reduce the concentrations of cefuroxime.

Cefuroxime is primarily eliminated by the kidney. Dose adjustments are recommended for patients with a CrCL less than 30 mls/min.

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June 1, 2023May 27, 2023

Risperidone Pharmacology Podcast

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On this episode, I discuss risperidone pharmacology, adverse effects, monitoring, and common indications.

There are numerous drug interactions that I discuss in this podcast episode. CYP2D6 inhibitors may increase drug concentrations.

Risperidone increases prolactin more than most 2nd generation antipsychotics. This can lead to sexual adverse effects.

QTC prolongation is a concern with all antipsychotics like risperidone. We can monitor EKG to monitor for this risk.

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May 25, 2023May 23, 2023

Vortioxetine Pharmacology Podcast

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On this podcast episode, I discuss vortioxetine pharmacology, adverse effects, drug interactions, and much more.

Because of vortioxetine’s long half-life, antidepressant discontinuation syndrome is going to be less prominent compared to ADPs with shorter half-lives.

Vortioxetine is metabolized by CYP2D6. Drugs that inhibit this enzyme will likely raise concentrations and place the patient more at risk for adverse effects.

I discuss rare vortioxetine adverse effects like hyponatremia and bleeding in this podcast episode.

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May 18, 2023May 9, 2023

Isosorbide Mononitrate Pharmacology Podcast

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On this episode, I discuss isosorbide mononitrate pharmacology, adverse effects, and important drug interactions.

Isosorbide mononitrate is a vasodilator that works by relaxing and widening the blood vessels (primarily veins) through nitric oxide action. This reduces the preload and oxygen demand on the heart.

The primary use for isosorbide mononitrate is angina prevention. It is important to remember that it is NOT meant for acute relief of chest pain.

Headache is a major adverse effect of isosorbide mononitrate and can be very bothersome for patients. Vasodilation is primarily responsible for this adverse effect.

PDE-5 inhibitors are notorious for causing drug interactions with any nitrate medication. I discuss management strategies in this podcast episode.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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May 11, 2023April 20, 2023

Azelastine Nasal Spray Pharmacology Podcast

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On this episode of the RLP podcast, I discuss azelastine nasal spray pharmacology, adverse effects, administration, and much more!

While most nasal sprays for allergic rhinitis are corticosteroids, azelastine is classified as an antihistamine.

Systemic absorption of azelastine is about 40%, so while not common, systemic adverse effects like sedation can happen.

On this podcast episode, I use azelastine to remind you about important education points regarding the use of nasal sprays.

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May 4, 2023April 17, 2023

Amlodipine Pharmacology Podcast

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On this episode of the Real Life Pharmacology Podcast, I discuss amlodipine pharmacology, adverse effects, and important drug interactions.

I break down why edema occurs with amlodipine on this episode of the Real Life Pharmacology podcast.

While beta-blockers are typically the first-line agent for the prevention of chronic angina symptoms, CCBs like amlodipine can be used as an alternative.

There are some potential CYP3A4 interactions with amlodipine. I discuss the severity of these interactions and how to monitor patients.

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April 27, 2023April 12, 2023

Pyridoxine Pharmacology

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On this episode, I discuss pyridoxine pharmacology, adverse effects, and important clinical uses.

Pyridoxine is most well known for its potential to reduce the likelihood of isoniazid-induced neuropathy.

Another common indication of pyridoxine is its use for nausea and vomiting associated with pregnancy.

Pyridoxine plays an important role in the production of heme, so deficiency will increase the risk for anemia.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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April 20, 2023April 12, 2023

Vibegron Pharmacology Podcast

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On this episode of the Real Life Pharmacology podcast, I discuss vibegron pharmacology, adverse effects, drug interactions and more!

I spend some time comparing and contrasting vibegron to mirabegron. Both are beta-3 agonists used for overactive bladder.

Vibegron dosing is very simple. It is dosed once daily with no alternative dosage forms available. The starting dose is the target dose.

Being primarily excreted in the feces and urine, vibegron doesn’t have many drug interactions.

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