Timolol Pharmacology Podcast

On this episode, I discuss timolol pharmacology, adverse effects, drug interactions, and much more.

Timolol is a non-selective beta-blocker so it blocks both beta-1 and beta-2 receptors.

Since timolol blocks beta-2 receptors, it can blunt the effect of respiratory medications that have beta-agonist action.

Beta-blockers are notorious for causing bradycardia and pulse is an important monitoring parameter for timolol.

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Food and Supplement Drug Interactions

On this episode of the Real Life Pharmacology Podcast, I cover some of the most common food and supplement drug interactions.

The 3 G’s can potentially increase the risk of bleeding in patients on anticoagulants and antiplatelets. I discuss what supplements these are.

There are some vitamins that can cause drug interactions. Vitamin C is a supplement that can alter the absorption of some medications.

Metal cations like iron can bind certain medications and reduce absorption. I discuss which medications are most likely to be affected.

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Vonoprazan Pharmacology – New Esophagitis Medication Class! Episode 326

On this episode, I discuss the new medication vonoprazan and where it will likely be used in practice.

Vonoprazan is from a brand new class of medication called “PCAB”. I discuss this medication and its pharmacology in this podcast episode.

Drug interactions and cost are the two major downsides of this medication that will likely limit its use compared to the PPIs.

CYP3A4 inducers like rifampin, carbamazepine, and phenytoin should not be used with vonoprazan. They will reduce the effectiveness of vonoprazan.

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Top 10 Anticoagulant Drug Interactions

Today’s sponsor of the Top 10 Anticoagulant Drug Interactions podcast is FreedAI. Freed listens, transcribes, and writes medical documentation for you.

FreedAI is offering a discount exclusive to RLP listeners! Users will get $50 off their first month with Freed! Use the discount code: RLPPOD

Apixaban is one of the most commonly used anticoagulants and there are some drug interactions you need to be aware of. Take a listen and find out!

Warfarin concentrations can substantially be elevated by drugs that inhibit CYP2C9. I cover a few of them in my top 10 anticoagulant drug interactions.

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Top 10 SSRI Drug Interactions Podcast

Today’s sponsor of the Top 10 SSRI Drug Interactions podcast is FreedAI. Freed listens, transcribes, and writes medical documentation for you.

FreedAI is offering a discount exclusive to RLP listeners! Users will get $50 off their first month with Freed! Use the discount code: RLPPOD

In this podcast episode, I discuss how to navigate SSRI drug interactions and identify some of the most common medications that have additive serotonergic activity.

SSRIs have antiplatelet activity. I discuss how to navigate using other medications that may increase bleed risk in combination with SSRIs.

Paroxetine and fluoxetine inhibit CYP2D6 I discuss how this can affect the benefits of tamoxifen therapy.

Fluvoxamine is a nasty medication with regard to the number of and significance of drug interactions. I outline important fluvoxamine interactions in this podcast episode.

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Navigating QTc Prolongation and Drug Interactions

On this episode, I discuss the pharmacology surrounding QTc prolongation and drug interactions.

I discuss which medications are more likely to cause QTc prolongation and which patient populations we should be more concerned about.

Antiarrhythmics are a common class of medication that can exacerbate QTc prolongation when used with other interacting medications.

500 ms is a common value utilized to help identify patients at risk for QTc prolongation and ultimately torsades de pointes.

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Risedronate Pharmacology Podcast

On this podcast episode, I cover risedronate pharmacology, adverse effects, drug interactions, and much more.

There is a strict administration procedure with risedronate which is designed to reduce adverse effects and enhance absorption. I discuss this in the podcast.

Many medications may cause osteoporosis and may precipitate treatment with risedronate. Corticosteroids and excessive thyroid hormone replacement are two examples.

Patients should remain upright (sitting or standing) for at least 30 minutes following administration to reduce the risk of esophagitis and ulceration.

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Antihypertensive Drug Interactions Podcast – Episode 316

On this podcast episode, I discuss some of the most common antihypertensive drug interactions you need to know.

One major interaction I discuss is the trifecta of a diuretic, an ACE or ARB, and an NSAID. This combination significantly increases the risk for acute renal failure.

Nitrates aren’t classically referred to as an antihypertensive but they can definitely cause some problems when combined with PDE5 Inhibitors.

Lithium can interact with 3 blood pressure medication classes. ACEIs, ARBs, and diuretics can all increase the risk for lithium toxicity.

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Teplizumab For Diabetes Episode 315 – Real Life Pharmacology Podcast

Teplizumab is a relatively new agent that helps delay the progression of type 1 diabetes. It slows the rate of beta-cell destruction in the pancreas.

Teplizumab is associated with cytokine release syndrome which can result in flu-like symptoms of fever, aches, and headache.

Cytokine release syndrome due to teplizumab can be reduced by using appropriate pretreatment medications. Those medications can include analgesics, antihistamines, and/or antiemetics.

Teplizumab is associated with suppressing the immune system so it is ideal to get vaccinations completed before using this medication. I go over the specific recommendations in the podcast episode.

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Captopril Pharmacology Podcast – Episode 314

On this podcast episode, I discuss captopril pharmacology, kinetics, interactions, and much more!

Captopril is an ACE Inhibitor. It can cause hyperkalemia, cough, and renal impairment.

One of the notable issues with captopril is its relatively short half-life which requires it to be dose frequently throughout the day.

Lithium is an important drug interaction and the use of captopril with this medication may increase concentrations and the chance for toxicity.

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