Tag: adverse effects

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December 15, 2022December 12, 2022

Propylthiouracil Pharmacology Podcast

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In this podcast episode, I cover propylthiouracil pharmacology, adverse effect, drug interaction, and much more!

Propylthiouracil carries a boxed warning for hepatotoxicity which is a significant downside compared to the other agent in its class (methimazole).

What about dosing? I discuss why this medication has to be dosed multiple times per day.

Drug interactions aren’t incredibly common with propylthiouracil but it can affect warfarin differently than most drug interactions. I discuss it further in this episode.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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December 8, 2022December 5, 2022

Brexpiprazole (Rexulti) Pharmacology Podcast

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Brexpiprazole (Rexulti) is a second generation antipsychotic. I discuss its pharmacology, adverse effects, drug interactions, and more in this podcast episode.

I like to associate brexpiprazole with aripiprazole. They have a lot of overlapping characteristics, particularly in relation to the adverse effect profile.

Brexpiprazole tends to have a low incidence of metabolic adverse effects which makes it a nice selection for patients who have diabetes, hypercholesterolemia, or who are overweight.

CYP3A4 and CYP2D6 are the two primary enzymes that break down brexpiprazole. I discuss the pharmacogenomic considerations associated with this medication.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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December 1, 2022November 23, 2022

Indapamide (Lozol) Pharmacology Podcast

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On this episode, I discuss indapamide pharmacology, adverse effects, drug interactions, and pharmacokinetics.

I discuss how indapamide differs from other thiazide diuretics. Particularly, I discuss indapamide compared to hydrochlorothiazide.

Frequent urination, hypokalemia, and dehydration are all possible risks with indapamide.

Pay attention to medications that can increase the risk for acute renal failure when added to indapamide. NSAIDs, ACEIs, ARBs, and other diuretics can increase this risk.

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November 24, 2022November 23, 2022

Tadalafil (Cialis) Pharmacology Podcast

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On this episode, I discuss tadalafil pharmacology, adverse effects, pharmacokinetics, and drug interactions.

Tadalafil has a significantly longer half-life than sildenafil. I discuss how this is going to impact a patient that may need a nitrate.

PDE-5 inhibitors like tadalafil are most commonly used for erectile dysfunction but I talk about other unique indications in the podcast.

Daily use or as-needed use of tadalafil are both acceptable options but there are some quirks you need to know with these two methods of use.

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November 17, 2022November 16, 2022

Sitagliptin Pharmacology Podcast

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Sitagliptin is a DPP4 inhibitor. I discuss the pharmacology of this medication on the podcast.

Which diabetes medication works similarly to sitagliptin? I discuss that further on this episode of the Real Life Pharmacology podcast.

Renal elimination plays a significant role with sitagliptin. I discuss how this impacts the appropriate dosing.

Cost is a significant issue with sitagliptin at this time. In addition, it’s A1C-lowering effects aren’t anything to write home about. I discuss how much it will lower A1C in this podcast episode.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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November 10, 2022November 9, 2022

Gabapentin (Neurontin) Pharmacology Podcast

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On this podcast episode, I discuss gabapentin (Neurontin) pharmacology, adverse effects, drug interactions, and much more!

Gabapentin’s GI absorption is a little wacky. I discuss on the podcast the clinical effects that this may have on our patients.

Renal elimination is critical to gabapentin. Worsening renal function will significantly impact the action of the drug.

CNS sedation can be a problem with gabapentin, especially in combination with other CNS depressants. I discuss this further on the podcast.

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October 27, 2022October 24, 2022

Lorazepam (Ativan) Pharmacology Podcast

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On this podcast episode, I discuss lorazepam (Ativan) pharmacology, adverse effects, and common drug interactions.

Lorazepam has numerous dosage forms and the IV formulation does contain propylene glycol which can accumulate if it is used for longer periods of time.

There is a boxed warning for lorazepam when it is used with opioids. The risk for opioid overdose, coma, and death increases significantly.

Lorazepam is an intermediate acting benzodiazpine. It’s half-life for most adult patients is in the 12-18 hour range.

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October 20, 2022October 24, 2022

Valsartan Pharmacology Podcast

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On this podcast episode, I discuss valsartan pharmacology, adverse effects, drug interactions, and much more.

Valsartan is a fairly common ARB. I mostly see losartan and valsartan used as the most common ARBs in hypertension management.

Valsartan has a longer half-life than losartan which is why we can often get away with once daily dosing compared to losartan which sometimes requires twice daily.

Hyperkalemia is a major concern with ARBs like valsartan. Trimethoprim and spironolactone are two medications that can increase this risk.

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October 13, 2022October 24, 2022

Famotidine Pharmacology Podcast

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On this podcast episode, I discuss famotidine pharmacology, adverse effects, uses, and drug interactions.

Famotidine is generally pretty well tolerated, but one thing I look out for with chronic use is B12 deficiency.

Famotidine is eliminated by the kidney so you should pay attention to the dose in patients with CKD.

Famotidine is occasionally used as a pretreatment to help prevent infusion-type reactions for certain chemotherapy agents.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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