Tag: adverse effects

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December 29, 2022December 16, 2022

Semaglutide (subQ) Pharmacology Podcast

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On this podcast episode, I discuss the pharmacology, adverse effects, and drug interactions of semaglutide.

Semaglutide has two primary uses: Type 2 diabetes and Weight Management – the dosing varies depending upon the indication.

When using semaglutide, pay attention to GI adverse effects. Nausea, diarrhea, and vomiting are the most common ADRs and are dose-dependent.

Pay attention to corticosteroid bursts. They can cause substantial hyperglycemia and counteract the effects of diabetes medications like semaglutide.

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December 22, 2022December 16, 2022

Minocycline Pharmacology Podcast

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Minocycline is a tetracycline antibiotic. I discuss pharmacology, adverse effects, and drug interactions.

Minocycline can cause sun sensitivity. Be sure to educate patients about this risk.

Metal cations like iron, zinc, calcium, and magnesium can bind minocycline and reduce the oral absorption of the medication.

Tooth discoloration is a possible adverse effect if minocycline is given to pediatric patients. I discuss it further in this episode.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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December 15, 2022December 12, 2022

Propylthiouracil Pharmacology Podcast

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In this podcast episode, I cover propylthiouracil pharmacology, adverse effect, drug interaction, and much more!

Propylthiouracil carries a boxed warning for hepatotoxicity which is a significant downside compared to the other agent in its class (methimazole).

What about dosing? I discuss why this medication has to be dosed multiple times per day.

Drug interactions aren’t incredibly common with propylthiouracil but it can affect warfarin differently than most drug interactions. I discuss it further in this episode.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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December 8, 2022December 5, 2022

Brexpiprazole (Rexulti) Pharmacology Podcast

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Brexpiprazole (Rexulti) is a second generation antipsychotic. I discuss its pharmacology, adverse effects, drug interactions, and more in this podcast episode.

I like to associate brexpiprazole with aripiprazole. They have a lot of overlapping characteristics, particularly in relation to the adverse effect profile.

Brexpiprazole tends to have a low incidence of metabolic adverse effects which makes it a nice selection for patients who have diabetes, hypercholesterolemia, or who are overweight.

CYP3A4 and CYP2D6 are the two primary enzymes that break down brexpiprazole. I discuss the pharmacogenomic considerations associated with this medication.

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December 1, 2022November 23, 2022

Indapamide (Lozol) Pharmacology Podcast

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On this episode, I discuss indapamide pharmacology, adverse effects, drug interactions, and pharmacokinetics.

I discuss how indapamide differs from other thiazide diuretics. Particularly, I discuss indapamide compared to hydrochlorothiazide.

Frequent urination, hypokalemia, and dehydration are all possible risks with indapamide.

Pay attention to medications that can increase the risk for acute renal failure when added to indapamide. NSAIDs, ACEIs, ARBs, and other diuretics can increase this risk.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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November 24, 2022November 23, 2022

Tadalafil (Cialis) Pharmacology Podcast

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On this episode, I discuss tadalafil pharmacology, adverse effects, pharmacokinetics, and drug interactions.

Tadalafil has a significantly longer half-life than sildenafil. I discuss how this is going to impact a patient that may need a nitrate.

PDE-5 inhibitors like tadalafil are most commonly used for erectile dysfunction but I talk about other unique indications in the podcast.

Daily use or as-needed use of tadalafil are both acceptable options but there are some quirks you need to know with these two methods of use.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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November 17, 2022November 16, 2022

Sitagliptin Pharmacology Podcast

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Sitagliptin is a DPP4 inhibitor. I discuss the pharmacology of this medication on the podcast.

Which diabetes medication works similarly to sitagliptin? I discuss that further on this episode of the Real Life Pharmacology podcast.

Renal elimination plays a significant role with sitagliptin. I discuss how this impacts the appropriate dosing.

Cost is a significant issue with sitagliptin at this time. In addition, it’s A1C-lowering effects aren’t anything to write home about. I discuss how much it will lower A1C in this podcast episode.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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November 10, 2022November 9, 2022

Gabapentin (Neurontin) Pharmacology Podcast

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On this podcast episode, I discuss gabapentin (Neurontin) pharmacology, adverse effects, drug interactions, and much more!

Gabapentin’s GI absorption is a little wacky. I discuss on the podcast the clinical effects that this may have on our patients.

Renal elimination is critical to gabapentin. Worsening renal function will significantly impact the action of the drug.

CNS sedation can be a problem with gabapentin, especially in combination with other CNS depressants. I discuss this further on the podcast.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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