Tag: adverse effects

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December 21, 2023December 18, 2023

Acamprosate Pharmacology Podcast – Episode 306

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On this podcast episode, I discuss acamprosate pharmacology, adverse effects, drug interactions, and much more!

Acamprosate’s most common adverse effect is diarrhea. It is a primary reason why patients will ask to stop taking this medication.

It is critical to assess renal function prior to using acamprosate. Dose adjustments are recommended when patients have a CrCl of less than 50 ml/min.

Unlike naltrexone, acamprosate avoids liver metabolism making it an alternative option in alcohol use disorder for patients who have liver impairment.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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December 14, 2023December 1, 2023

Alfuzosin Pharmacology Podcast

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On this podcast episode, I discuss alfuzosin pharmacology, adverse effects, drug interactions, and much more!

Alfuzosin is an alpha blocker used to help relieve the symptoms of BPH.

Low blood pressure is a possible adverse effect of alfuzosin and is more likely when combined with PDE-5 inhibitors like sildenafil.

CYP3A4 is an important enzyme in the metabolism of alfuzosin. Inhibitors of CYP3A4 can raise concentrations and increase the chance of alfuzosin toxicity.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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December 7, 2023November 28, 2023

Methadone Pharmacology Podcast

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In this podcast episode, I discuss methadone pharmacology, adverse effects, drug interactions, and pharmacokinetics.

Methadone is a full opioid agonist that may be used for pain management and opioid use disorder.

Transitioning from methadone to another opioid is complicated. I discuss conversion in this podcast episode.

Methadone can increase the risk of QTc prolongation and also has a lot of drug interactions. I discuss them in detail in this podcast episode.

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November 30, 2023November 28, 2023

Meperidine Pharmacology Podcast

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On this podcast episode, I discuss meperidine pharmacology, adverse effects, pharmacokinetics, drug interactions, and much more!

Meperidine is an opioid that is seldom used due to neurotoxicity. I describe how this can happen in this podcast episode.

Meperidine has numerous drug interactions and using a CYP3A4 inhibitor may increase the risk for toxicity.

Seizures are a risk with meperidine due to its neurotoxic metabolite normeperidine. I discuss this further in this podcast episode.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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November 23, 2023November 23, 2023

Guanfacine Pharmacology Podcast

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On this episode of the podcast, I cover guanfacine pharmacology, adverse effects, drug interactions, and much more.

Guanfacine is a central acting alpha-2 agonist that has the brand names of Tenex and Intuniv.

Because of guanfacine’s mechanism of action, it suppresses the sympathetic response leading to a drop in pulse and blood pressure.

It is important to remind patients that the onset of action is slow in the management of ADHD with guanfacine. I discuss this further in this podcast episode.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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November 16, 2023November 14, 2023

Fluvastatin Pharmacolgy Podcast

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On this podcast episode, I discuss fluvastatin pharmacology, adverse effects, pharmacokinetics, and much more.

Fluvastatin is only a low to moderate-intensity statin which explains its limited use compared to rosuvastatin or atorvastatin.

I discuss drug interactions in the podcast but one important one to recognize is drugs that can inhibit CYP2C9.

Fluvastatin is considered a lipophilic statin. I have previously discussed this on the Meded101 blog which you can find here.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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November 9, 2023November 7, 2023

Oxymorphone Pharmacology Podcast

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In this episode, I discuss oxymorphone pharmacology, adverse effects, drug interactions, and more!

Oxymorphone is approximately 3 times more potent than morphine. I break down some common opioid comparisons in this episode.

Oxymorphone avoids many of the CYP interactions. I discuss some of the common interactions in this episode.

I discuss histamine release in relation to opioids and oxymorphone and specifically how this may impact our patients.

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November 2, 2023November 4, 2023

Diclofenac Pharmacology Podcast

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On this podcast episode, I discuss diclofenac pharmacology, adverse effects, drug interactions, and much more.

Diclofenac is one of the highest-risk NSAIDs when it comes to cardiovascular risk. You can find more information on this in the Meded101 NSAID comparison table.

Diclofenac carries two boxed warnings. One is for GI bleed risk and the other is for cardiovascular risks.

Anticoagulants, antiplatelets, diuretics, and ACEs/ARBs are all common medication classes that can interact with diclofenac.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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October 26, 2023October 23, 2023

Aliskiren Pharmacology Podcast

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On this episode, I discuss aliskiren pharmacology, adverse effects, drug interactions, and much more.

Aliskiren should not be used with ACE Inhibitors or ARBs. I discuss why that is in this episode.

Aliskiren has a long enough half-life at approximately 24 hours so it is recommended to only take this once daily.

Hyperkalemia is a major concern with aliskiren. It is important to monitor potassium levels and renal function.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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