Category: Renal, Urology, and Electrolyte Medications

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Calcium Acetate Pharmacology

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Calcium Acetate (PhosLo) is used in the management of hyperphosphatemia associated with CKD.

Important monitoring parameters for calcium acetate include phosphorus, calcium, PTH, and renal function.

There are numerous binding interactions with calcium acetate. It can reduce concentrations of some HIV drugs, antibiotics, and thyroid supplements. I discuss more examples in the podcast.

Thiazide diuretic in combination with calcium acetate may increase the risk for hypercalcemia.

I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

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Mirabegron Pharmacology

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Mirabegron is a beta-3 agonist that can help relax bladder smooth muscle and manage symptoms of overactive bladder.

Mirabegron inhibits CYP2D6 which can negatively impact the effectiveness of tamoxifen. I discuss this in greater detail in the podcast.

Tramadol and codeine effectiveness can be impacted by mirabegron. Be aware of this when using this medication.

By inhibiting CYP2D6, mirabegron can increase the concentrations of many psychotropic medications such as fluoxetine, aripiprazole, clozapine, and paroxetine. I discuss this further in this episode of the podcast.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

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Magnesium Pharmacology

Magnesium Pharmacology

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On this episode, I discuss magnesium pharmacology and the clinical applications. Magnesium plays numerous important functions in the body and you may see patients take these supplements under the direction of a healthcare professional and sometimes on their own.

It is very important to remember that magnesium can cause GI upset and diarrhea. This is often overlooked in our polypharmacy patient.

Magnesium can accumulate in renal disease. This is important to remember especially in patients who have a tendency to take a lot of supplements without discussing them with a healthcare professional.

PPI’s are a notorious cause of low magnesium. Loop diuretics can increase magnesium excretion and also cause low magnesium levels.

Magnesium can bind up numerous drugs reducing concentrations and leading to treatment failure. A few examples include quinolone antibiotics, tetracycline antibiotics, and levothyroxine.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

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Potassium Supplement Pharmacology

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On this episode I discuss why we may need to use potassium supplements.

I also talk about a medication error situation involving potassium that lead to a death.

It is important to remember other medications that can raise potassium levels.

I also talk about a dosage form of potassium that might make patients ask some questions.

Enjoy the show and I hope you sign up to get our free 31 page PDF!

 

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Alpha Blockers Pharmacology RLP Episode 017

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On this episode, I discuss the pharmacology and side effects of alpha blockers as well as the differences between a selective alpha blocker versus a non-selective alpha blocker. Enjoy!

All subscribers to the website/podcast will get access to a FREE Top 200 Drug Study Guide where I highlight the 3 most highly testable pearls from each medication (this is a 31 page PDF!)  In addition, you’ll get a free 100 question pharmacology test.  Both resources are free, simply for following the podcast!  What are you waiting for? Click Here to Subscribe

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5-Alpha-Reductase Inhibitors RLP Episode 016

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5 Alpha-Reductase Inhibitors are most often used in the setting of BPH.  I discuss mechanism of action, uses, adverse drug reactions as well as some medications that can exacerbate BPH.  Hope you enjoy the episode!

All subscribers to the website/podcast will get access to a FREE Top 200 Drug Study Guide where I highlight the 3 most highly testable pearls from each medication (this is a 31 page PDF!)  In addition, you’ll get a free 100 question pharmacology test.  Both resources are free, simply for following the podcast!  What are you waiting for? Click Here to Subscribe