Risedronate Pharmacology Podcast

On this podcast episode, I cover risedronate pharmacology, adverse effects, drug interactions, and much more.

There is a strict administration procedure with risedronate which is designed to reduce adverse effects and enhance absorption. I discuss this in the podcast.

Many medications may cause osteoporosis and may precipitate treatment with risedronate. Corticosteroids and excessive thyroid hormone replacement are two examples.

Patients should remain upright (sitting or standing) for at least 30 minutes following administration to reduce the risk of esophagitis and ulceration.

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Methadone Pharmacology Podcast

In this podcast episode, I discuss methadone pharmacology, adverse effects, drug interactions, and pharmacokinetics.

Methadone is a full opioid agonist that may be used for pain management and opioid use disorder.

Transitioning from methadone to another opioid is complicated. I discuss conversion in this podcast episode.

Methadone can increase the risk of QTc prolongation and also has a lot of drug interactions. I discuss them in detail in this podcast episode.

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Meperidine Pharmacology Podcast

On this podcast episode, I discuss meperidine pharmacology, adverse effects, pharmacokinetics, drug interactions, and much more!

Meperidine is an opioid that is seldom used due to neurotoxicity. I describe how this can happen in this podcast episode.

Meperidine has numerous drug interactions and using a CYP3A4 inhibitor may increase the risk for toxicity.

Seizures are a risk with meperidine due to its neurotoxic metabolite normeperidine. I discuss this further in this podcast episode.

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Oxymorphone Pharmacology Podcast

In this episode, I discuss oxymorphone pharmacology, adverse effects, drug interactions, and more!

Oxymorphone is approximately 3 times more potent than morphine. I break down some common opioid comparisons in this episode.

Oxymorphone avoids many of the CYP interactions. I discuss some of the common interactions in this episode.

I discuss histamine release in relation to opioids and oxymorphone and specifically how this may impact our patients.

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Diclofenac Pharmacology Podcast

On this podcast episode, I discuss diclofenac pharmacology, adverse effects, drug interactions, and much more.

Diclofenac is one of the highest-risk NSAIDs when it comes to cardiovascular risk. You can find more information on this in the Meded101 NSAID comparison table.

Diclofenac carries two boxed warnings. One is for GI bleed risk and the other is for cardiovascular risks.

Anticoagulants, antiplatelets, diuretics, and ACEs/ARBs are all common medication classes that can interact with diclofenac.

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Meloxicam Pharmacology Podcast

I discuss meloxicam pharmacology, adverse effects, drug interactions, and much more on this episode of the Real Life Pharmacology Podcast.

Meloxicam tends to have a greater affinity to COX-2 versus COX-1. I discuss what this means clinically on this episode.

Important meloxicam drug interactions include anticoagulants, antiplatelet medications, renal impairing drugs, and lithium amongst others.

Meloxicam has a longer half-life than many NSAIDs and because of this can be dosed once daily for pain relief.

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Etanercept Pharmacology Podcast

On this podcast episode, I cover etanercept pharmacology, adverse effects, drug interactions and much more.

Etanercept is classified as a DMARD but is different from older DMARDs in that it is a biologic agent and needs to be injected.

Vaccination assessment in patients is important prior to initiating etanercept due to the fact that the medication may blunt the effectiveness of the vaccines.

Immunosuppression from etanercept can lead to an increased risk for infection and malignancy.

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Pregabalin Pharmacology Podcast

On this podcast episode, I discuss (Lyrica) pregabalin pharmacology, adverse effects, drug interactions, and much more.

I compare pregabalin and gabapentin in this episode and one important difference is the percent absorption of gabapentin compared to pregabalin.

Pregabalin can exacerbate the risk of respiratory depression and overdose in patients who are taking opioids.

Pregabalin is most frequently used in practice for neuropathic pain syndromes.

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Phenobarbital Pharmacology Podcast

On this episode of the Real Life Pharmacology Podcast, I cover phenobarbital pharmacology, adverse effects, important drug interactions and much more.

Phenobarbital is an enzyme inducer. It is an inducer at CYP3A4 so this can lead to numerous drug interactions.

Phenobarbital can exacerbate the risk for opioid overdose and increase the risk for respiratory depression and death.

Phenobarbital can deplete numerous vitamins such as vitamin D, folic acid, and vitamin B12. Monitoring of these is important.

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Pyridostigmine Pharmacology Podcast

I discuss Pyridostigmine Pharmacology in this podcast episode in addition to adverse effects, drug interactions, and much more!

Pyridostigmine is an acetylcholinesterase inhibitor that can be used for myasthenia gravis or orthostasis.

Pyridostigmine can blunt the effect of neuromuscular blocking agents so patients undergoing surgery should be sure to have a game plan with their surgery team.

Similar to donepezil, pyridostigmine can cause diarrhea and bradycardia.

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