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March 20, 2025March 16, 2025

Loratadine Pharmacology Podcasst

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On this podcast episode, I cover loratadine pharmacology, adverse effects, drug interactions, and much more.

Loratatdine is a second generation antihistamine. It has a lower incidence of central nervous system adverse effects compared to first-generation antihistamines like diphenhydramine.

Loratadine dosing varies in pediatric patients and those with renal impairment. I get into the details on this podcast episode.

Drug interactions aren’t common with loratadine but I discuss a few that may be clinically significant.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

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March 13, 2025March 11, 2025

Modafinil Pharmacology Podcast

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Modafinil (Provigil) is a CNS stimulant medication. I cover modafinil pharmacology, adverse effects, drug interactions, and much more on this podcast episode.

You should be aware that modafinil is a Schedule 4 controlled substance so it does carry a risk of dependence and addiction.

Modafinil can cause CYP3A4 induction and lead to lowering the concentrations of many medications. This includes antiepileptic agents and oral contraceptives.

The most common adverse effects of modafinil include ramping up the body and causing symptoms such as anxiety and insomnia.

Cardiovascular changes are a risk with modafinil as this medication can contribute to hypertension and tachycardia.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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March 6, 2025March 4, 2025

Top 200 Drugs Podcast – Medications 196-200

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Lansoprazole is a PPI that can be used for GERD, ulcers, and other GI conditions. B12 and magnesium deficiency are possible long-term mineral and vitamin effects.

Augmentin is a combination medication of amoxicillin and clavulanate. It is an antibiotic for infection. Diarrhea is the most common adverse effect.

Lovastatin is a cholesterol-lowering medication. It is often not a preferred statin due to CYP3A4 interaction and it is less potent than other medications.

Valacyclovir is a prodrug that gets converted to acyclovir. It is an antiviral medication and can treat herpes zoster and herpes simplex infections.

Chlorpromazine is a dopamine antagonist that has anticholinergic activity as well. It is a first-generation antipsychotic medication.

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February 27, 2025February 26, 2025

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Top 200 Drugs Podcast – Medications 191-195

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Clopidogrel (Plavix) is an antiplatelet medication. You need to understand the pharmacokinetics of clopidogrel and how CYP2C19 affects this medication.

Doxycycline is a tetracycline antibiotic. Calcium, iron, and other metal cations can bind doxycycline and reduce the absorption of the medication.

Hyzaar is a combination of losartan and hydrochlorothiazide. Losartan is an ARB and hydrochlorothiazide is a thiazide diuretic.

Kytril (granisetron) is an antiemetic medication. It is from the same class of medication as the more commonly used ondansetron.

Restoril (temazepam) is a benzodiazepine. It is primarily used to treat insomnia as it has a much shorter half-life than many of the other benzodiazepines.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

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February 20, 2025February 12, 2025

Top 200 Drugs Podcast – Medications 186-190

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On this episode of the Real Life Pharmacology Podcast, we will cover medications 186-190 on the Top 200 Drugs List.

The medications included in the podcast episode are Sonata, Zebata, Zovirax, Coumadin, and Luvox.

Sonata (ezopiclone) is a Z-drug used for insomnia. It has many similar effects to benzodiazepines and a similar mechanism of action.

Zebeta (bisoprolol) is a beta-blocker used for the treatment of hypertension, atrial fibrillation, and heart failure amongst other indication.

Zovirax (acyclovir) is an antiviral medication used to treat various viral infection. It needs to be dosed numerous times throughout the day which is a downside to use.

Coumadin (warfarin) is an anticoagulant. It is most well known for its need to have INRs drawn to assess drug levels.

Luvox (fluvoxamine) is an SSRI antidepressant. It is well known for its ability to cause drug interaction and is often not a first line agent because of this reason.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

February 13, 2025February 1, 2025

Top 200 Drugs – Medications 181-185

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On this Real Life Pharmacology Podcast episode, we cover medications 181-185.

Proscar is the brand name for finasteride. This medication can be helpful in shrinking the size of the prostate but it does typically take a while to work (months).

Sinemet is a combination of carbidopa and levodopa. Levodopa is converted in the central nervous system to dopamine to help alleviate a shortage of dopamine in the brain.

Risedronate is a bisphosphonate medication that can be used in the treatment of osteoporosis.

Albuterol (Ventolin) is a short-acting beta-agonist that is used to relieve symptoms of acute respiratory distress most often associated with an asthma exacerbation.

Tramadol is classified as an opioid analgesic. It also has activity similar to SNRIs as it has the ability to increase serotonin and norepinephrine in the brain.

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February 6, 2025February 1, 2025

Top 200 Drugs – Medications 176-180

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Prednisolone is a corticosteroid that is often used in pediatrics. Hyperglycemia, insomnia, and GI upset are relatively common adverse effects.

Ibuprofen is a commonly used OTC pain reliever. It is classified as an NSAID and can increase GI bleed risk and exacerbate heart failure.

Aceon is the brand name for perindopril. ACE inhibitors are well known to cause drug induced cough and will cause hyperkalemia.

Trazodone is classified as an antidepressant but is frequently used to treat insomnia because of its sedative properties.

Pioglitazone is an oral anti-diabetes medication that should be avoided in patients with heart failure.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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January 30, 2025January 28, 2025

Top 200 Drugs Podcast – Medications 171-175

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On this episode of the Top 200 drugs podcast, we are going to cover these 5 medications: Cyclosporine, insulin glargine, tadalafil, amitriptyline, and gemfibrozil.

Cyclosporine is a calcineurin inhibitor that suppresses the immune system. This is useful in patients who have had an organ transplant.

Insulin glargine is a long-acting insulin product that can be used in type 1 and type 2 diabetes. I discuss adverse effects, dosing, and much more.

Tadalafil is a PDE-5 inhibitor that can be used to treat sexual dysfunction. The nitrate drug interaction is one of the most highly tested drug interactions in school.

Amitriptyline is a TCA. It is highly anticholinergic and because of this is not a great medication to utilize in elderly patients.

Gemfibrozil is primarily used to lower triglyceride levels. This medication can significantly increase the risk for rhabdomyolysis in patients taking statin medications.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

Support The Podcast and Check Out These Amazing Resources!

Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

Guide to Drug Food Interactions (Amazon Best Seller)